Hydrogen / Deuterium / Tritium
Ordinary water / Heavy water
Deuterium-Tritium fusion yields 17.6 MeV of energy but requires a temperature of approximately 40 million Kelvins to overcome the coulomb barrier and ignite it. Thus, it takes considerable energy to force nuclei to fuse, even those of the lightest element, hydrogen. This is because all nuclei have a positive charge due to their protons, and as like charges repel each other, nuclei strongly resist being put too close together. Heated to thermonuclear temperatures, they can overcome this electromagnetic repulsion and get close enough for the attractive nuclear force to be sufficiently strong to achieve fusion.